A sarcomere is the basic unit of a muscle's cross-striated myofibril. Sarcomeres are multi-protein complexes composed of three different filament systems.
The thick filament system is composed of Myosin protein which is connected from the M-line to the Z-disc by titin. It also contains myosin-binding protein C which binds at one end to the thick filament and the other to Actin.
The thin filaments are assembled by Actin monomers bound to nebulin, which also involves tropomyosin (a dimer which coils itself around the F-actin core of the thin filament) and troponin.
Nebulin and titin give stability and structure to the sarcomere.
A muscle cell from a biceps may contain 100,000 sarcomeres. The myofibrils of smooth muscle cells are not arranged into sarcomeres.
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